PepEvolution
HomeRankingsTirzepatide
MetabolicFully audited

Tirzepatide

Mounjaro / Zepbound

A+ science, B-grade reality. The example that proves the system: we grade what you buy and inject, not just the trial.

Verdict, B · Viable

The science is A+, FDA-approved, unimpeachable. But the way you’ll actually source it (gray-market counterfeit risk) and tolerate it (boxed thyroid warning, GI burden, lean-mass loss) is a B. We grade what you buy and inject, not just the trial.

Overview

Tirzepatide is a dual GIP/GLP-1 receptor agonist with unimpeachable, FDA-approved clinical evidence (SURMOUNT-1, n=2,539). Yet the way a buyer actually sources it (gray-market counterfeit risk) and tolerates it (boxed thyroid C-cell warning, GI burden, lean-mass loss) is materially harder than the trial data alone implies.

Tirzepatide dosage, what the research shows →

Doses used in published studies, reconstitution math, half-life and safety notes. Cited, educational.

PepScore Breakdown, the four axes

Evidence

35% weight
100/100

How strong is the published human science?

Human data depth40/40
Regulatory & registry status30/30
Reproducibility & consistency20/20
Mechanism characterized in humans10/10

Sourcing & COA

30% weightOur moat
70/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing25/35
Method transparency (HPLC + MS + endotoxin/sterility, methods stated)18/25
Lot-matched + recent17/25
Independent corroboration10/15

Safety & Risk

25% weight
58/100

What is the real-world harm potential?

Documented AEs / toxicity22/40
Contraindication breadth15/25
Regulatory warnings10/20
Therapeutic index / margin11/15

Practicality

10% weight
73/100

How easy is it to actually run a verified version?

Verified-source availability30/35
Cost / value per cycle18/25
Reconstitution & administration16/25
Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

Best-Sourced Vendor

Amino Club

Vendor 83 · A

Strong vendor grade (A) and the best verified supply right now for Tirzepatide, batch-matched independent COA freshness 90%.

Visit Amino Club ↗

Ranked by Source Match = Vendor Grade × batch-COA freshness. Affiliate status is never an input to any grade, and a paying vendor never outranks a non-paying one on a tie.How this works →

Want a clinical path?

Talk to a licensed provider about Tirzepatide and whether it's appropriate for your situation.

Talk to a Provider ↗

Telehealth. Not medical advice, for educational purposes.

PepScore78/100 · B
Last gradedJune 28, 2026
Next re-grade triggerA new counterfeit-supply readout or a change in compounding/shortage status would move Sourcing.

Get the PepEvolution Dispatch

Monthly COA findings, vendor changes, and new grades. Research/educational only, no spam.

Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.