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TB-500 Fragment

The active Tβ4 17-23 fragment of TB-500 — less studied and less available than the full peptide with a thinner evidence base.

Verdict — D · Speculative

A derivative compound with less data and less availability than the full TB-500 peptide. For buyers who want thymosin beta-4 axis activity, full TB-500 from a COA-verified vendor is the better-supported choice at this time.

Overview

TB-500 Fragment refers to the active thymosin β4 (17-23) sub-sequence proposed to carry the G-actin sequestering activity of the full TB-500 peptide. The hypothesis is that this shorter fragment retains key activity with a simpler synthesis, but the human evidence base is considerably thinner than for full TB-500 and sourcing is more limited. The theoretical cell-proliferation concern present for TB-500 carries over.

PepScore Breakdown — the four axes

Evidence

35% weight
26/100

How strong is the published human science?

Human data depth8/40
Regulatory & registry status4/30
Reproducibility & consistency8/20
Mechanism characterized in humans6/10

Sourcing & COA

30% weightOur moat
46/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing16/35
Verified purity %14/30
COA transparency & batch traceability9/20
Multi-vendor verified availability7/15

Safety & Risk

25% weight
68/100

What is the real-world harm potential?

Documented AEs / toxicity28/40
Contraindication breadth17/25
Regulatory warnings12/20
Therapeutic index / margin11/15

Practicality

10% weight
60/100

How easy is it to actually run a verified version?

Verified-source availability18/35
Cost / value per cycle14/25
Reconstitution & administration18/25
Storage & stability10/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

Want a clinical path?

Talk to a licensed provider about TB-500 Fragment and whether it's appropriate for your situation.

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Telehealth. Not medical advice — for educational purposes.

PepScore46/100 · D
Last gradedJune 28, 2026
Next re-grade triggerA comparative human trial vs full TB-500 would be the primary grade mover.

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Educational only — not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links — this never affects grades. Consult a licensed healthcare provider before using any compound.