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SkinPreliminary grade

Melanotan II

MT-II

A potent tanning and libido melanocortin agonist — gray-market, not approved, and carries a real melanoma proliferation concern.

Verdict — D · Speculative

Real tanning and libido effects are documented, but a plausible melanoma proliferation signal, spontaneous erections, nausea, and an unverified gray-market supply make this a D-grade compound. The risk-benefit ratio is unfavorable for most buyers. Not approved for any indication.

Overview

Melanotan II (MT-II) is a cyclic melanocortin agonist that promotes eumelanin production (darkening tan), suppresses appetite, and stimulates erectile function. It has significant gray-market use and some published human data, but it has never received regulatory approval. Key safety concerns include: potential melanocytic proliferation (melanoma risk signal, not proven causal but biologically plausible), spontaneous erections and priapism risk, nausea at typical doses, and transient BP changes. The FDA has issued warnings about unapproved injectable tanning products.

PepScore Breakdown — the four axes

Evidence

35% weight
42/100

How strong is the published human science?

Human data depth16/40
Regulatory & registry status6/30
Reproducibility & consistency12/20
Mechanism characterized in humans8/10

Sourcing & COA

30% weightOur moat
60/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing20/35
Verified purity %17/30
COA transparency & batch traceability12/20
Multi-vendor verified availability11/15

Safety & Risk

25% weight
39/100

What is the real-world harm potential?

Documented AEs / toxicity14/40
Contraindication breadth10/25
Regulatory warnings8/20
Therapeutic index / margin7/15

Practicality

10% weight
67/100

How easy is it to actually run a verified version?

Verified-source availability22/35
Cost / value per cycle18/25
Reconstitution & administration18/25
Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

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PepScore49/100 · D
Last gradedJune 28, 2026
Next re-grade triggerDefinitive human melanoma risk data would either confirm the signal (worsening the grade) or rule it out (improving Safety). Neither is likely to come from industry.

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Educational only — not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links — this never affects grades. Consult a licensed healthcare provider before using any compound.