MetabolicPreliminary grade

Mazdutide

China-approved dual GLP-1/glucagon agonist (NMPA 2025) — robust GLORY program data, very limited Western sourcing.

Verdict — C · Emerging / Mixed

NMPA-approved with strong phase-3 data, but Western availability is near-zero and any gray-market material should be treated with high skepticism. A China-validated compound with limited reach outside that market today.

PepScore / 100

CEmerging / Mixed

How we compute this →

Overview

Mazdutide (IBI362, Innovent Biologics) is a dual GLP-1/glucagon receptor agonist that received NMPA approval in China in 2025 for weight management following the GLORY phase-3 program. Phase-3 data show approximately 16-18% weight loss. Western regulatory approval has not been sought; sourcing outside mainland China is essentially unverified.

PepScore Breakdown — the four axes

Evidence

35% weight

70/100

How strong is the published human science?

Human data depth28/40

Regulatory & registry status22/30

Reproducibility & consistency12/20

Mechanism characterized in humans8/10

Sourcing & COA

30% weightOur moat

38/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing14/35

Verified purity %12/30

COA transparency & batch traceability7/20

Multi-vendor verified availability5/15

Safety & Risk

25% weight

48/100

What is the real-world harm potential?

Documented AEs / toxicity18/40

Contraindication breadth11/25

Regulatory warnings10/20

Therapeutic index / margin9/15

Practicality

10% weight

51/100

How easy is it to actually run a verified version?

Verified-source availability14/35

Cost / value per cycle12/25

Reconstitution & administration16/25

Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

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PepScore53/100 · C

Last gradedJune 28, 2026

Next re-grade triggerA Western regulatory filing (FDA/EMA) or licensed import program would lift Sourcing and Practicality.

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