Growth HormonePreliminary grade

HGH

Somatropin

The gold-standard GH compound, FDA-approved for six indications, decades of RCT data, and the hardest to source cleanly.

Verdict, B · Viable

The most evidence-rich GH compound in the catalog, FDA-approved, decades of RCT data. But off-label body-composition use is weaker, IGF-1 elevation carries real cancer-signal concern, and gray-market sourcing is genuinely hazardous. Rx-only through a licensed clinic is the only acceptable path.

PepScore / 100

BViable

How we compute this →

Overview

Recombinant human growth hormone (somatropin) has the most extensive clinical evidence base of any GH-axis compound, FDA-approved for pediatric GH deficiency, adult GH deficiency, short stature, HIV wasting, and more since 1985. Off-label use in healthy adults for body composition and anti-aging is widespread but poorly supported by registered trials and carries real IGF-1-elevation risks. Sourcing is the critical bottleneck: branded somatropin requires a prescription, and gray-market vials carry severe counterfeiting and batch-mislabeling risk.

PepScore Breakdown, the four axes

Evidence

35% weight

96/100

How strong is the published human science?

Human data depth38/40

Regulatory & registry status29/30

Reproducibility & consistency19/20

Mechanism characterized in humans10/10

Sourcing & COA

30% weightOur moat

64/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing22/35

Method transparency (HPLC + MS + endotoxin/sterility, methods stated)16/25

Lot-matched + recent16/25

Independent corroboration10/15

Safety & Risk

25% weight

59/100

What is the real-world harm potential?

Documented AEs / toxicity22/40

Contraindication breadth15/25

Regulatory warnings12/20

Therapeutic index / margin10/15

Practicality

10% weight

67/100

How easy is it to actually run a verified version?

Verified-source availability26/35

Cost / value per cycle12/25

Reconstitution & administration20/25

Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

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PepScore74/100 · B

Last gradedJune 28, 2026

Next re-grade triggerA legitimate Rx source through a licensed clinic would lift Sourcing; a large body-composition RCT in healthy adults would strengthen the off-label evidence case.

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Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.

HGH