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LongevityPreliminary grade

DSIP

A 1970s sleep-and-stress peptide whose human evidence stayed sparse and inconsistent for half a century.

Verdict — C · Emerging / Mixed

A long-standing sleep peptide that never accumulated the evidence to match its longevity — sparse, inconsistent human data and an under-characterised mechanism. No major safety signal, but a C: for the experienced, on thin evidence and unverified supply.

Overview

Delta-sleep-inducing peptide (DSIP) was isolated by Schoenenberger and Monnier in the 1970s and named for its proposed sleep-promoting activity. Despite decades of availability, the human evidence base remained small and inconsistent, with unclear pharmacokinetics and a mechanism that is still poorly characterised. It is used in the gray market as a sleep and anti-stress aid. There is no major documented safety signal, but the absence of robust modern trials and verified sourcing keeps it firmly mid-pack.

PepScore Breakdown — the four axes

Evidence

35% weight
33/100

How strong is the published human science?

Human data depth12/40
Regulatory & registry status6/30
Reproducibility & consistency9/20
Mechanism characterized in humans6/10

Sourcing & COA

30% weightOur moat
52/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing17/35
Verified purity %16/30
COA transparency & batch traceability10/20
Multi-vendor verified availability9/15

Safety & Risk

25% weight
67/100

What is the real-world harm potential?

Documented AEs / toxicity26/40
Contraindication breadth17/25
Regulatory warnings13/20
Therapeutic index / margin11/15

Practicality

10% weight
62/100

How easy is it to actually run a verified version?

Verified-source availability20/35
Cost / value per cycle16/25
Reconstitution & administration18/25
Storage & stability8/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

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PepScore50/100 · C
Last gradedJune 28, 2026
Next re-grade triggerA modern controlled sleep trial with defined pharmacokinetics would clarify the grade.

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