PepEvolution
HomeRankingsDSIP
LongevityPreliminary grade

DSIP

A 1970s sleep-and-stress peptide whose human evidence stayed sparse and inconsistent for half a century.

Verdict, C · Emerging / Mixed

A long-standing sleep peptide that never accumulated the evidence to match its longevity, sparse, inconsistent human data and an under-characterised mechanism. No major safety signal, but a C: for the experienced, on thin evidence and unverified supply.

Overview

Delta-sleep-inducing peptide (DSIP) was isolated by Schoenenberger and Monnier in the 1970s and named for its proposed sleep-promoting activity. Despite decades of availability, the human evidence base remained small and inconsistent, with unclear pharmacokinetics and a mechanism that is still poorly characterised. It is used in the gray market as a sleep and anti-stress aid. There is no major documented safety signal, but the absence of robust modern trials and verified sourcing keeps it firmly mid-pack.

PepScore Breakdown, the four axes

Evidence

35% weight
33/100

How strong is the published human science?

Human data depth12/40
Regulatory & registry status6/30
Reproducibility & consistency9/20
Mechanism characterized in humans6/10

Sourcing & COA

30% weightOur moat
52/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing18/35
Method transparency (HPLC + MS + endotoxin/sterility, methods stated)13/25
Lot-matched + recent13/25
Independent corroboration8/15

Safety & Risk

25% weight
67/100

What is the real-world harm potential?

Documented AEs / toxicity26/40
Contraindication breadth17/25
Regulatory warnings13/20
Therapeutic index / margin11/15

Practicality

10% weight
62/100

How easy is it to actually run a verified version?

Verified-source availability20/35
Cost / value per cycle16/25
Reconstitution & administration18/25
Storage & stability8/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

Want a clinical path?

Talk to a licensed provider about DSIP and whether it's appropriate for your situation.

Talk to a Provider ↗

Telehealth. Not medical advice, for educational purposes.

PepScore50/100 · C
Last gradedJune 28, 2026
Next re-grade triggerA modern controlled sleep trial with defined pharmacokinetics would clarify the grade.

Get the PepEvolution Dispatch

Monthly COA findings, vendor changes, and new grades. Research/educational only, no spam.

Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.