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MetabolicPreliminary grade

Retatrutide

A triple GIP/GLP-1/glucagon agonist showing >20% weight loss in phase 2, the most powerful incretin in the pipeline.

Verdict, C · Emerging / Mixed

Unprecedented phase-2 weight-loss signal and strong phase-3 enrollment, but no approval, limited independent sourcing, and an expected GLP-1-class safety profile with additional glucagon-axis unknowns. Watch the TRIUMPH readout; buy nothing from the gray market.

Overview

Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist (Eli Lilly) currently in phase-3 TRIUMPH trials with no regulatory approval yet. Phase-2 data demonstrated up to 24% body-weight reduction, the largest in any published incretin trial. Gray-market supply exists but is unverified; the compound is not yet commercially manufactured for consumer use.

PepScore Breakdown, the four axes

Evidence

35% weight
80/100

How strong is the published human science?

Human data depth30/40
Regulatory & registry status26/30
Reproducibility & consistency15/20
Mechanism characterized in humans9/10

Sourcing & COA

30% weightOur moat
42/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing15/35
Method transparency (HPLC + MS + endotoxin/sterility, methods stated)11/25
Lot-matched + recent10/25
Independent corroboration6/15

Safety & Risk

25% weight
48/100

What is the real-world harm potential?

Documented AEs / toxicity18/40
Contraindication breadth12/25
Regulatory warnings9/20
Therapeutic index / margin9/15

Practicality

10% weight
52/100

How easy is it to actually run a verified version?

Verified-source availability15/35
Cost / value per cycle12/25
Reconstitution & administration16/25
Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

Best-Sourced Vendor

Amino Club

Vendor 83 · A

Strong vendor grade (A) and the best verified supply right now for Retatrutide, batch-matched independent COA freshness 90%.

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Ranked by Source Match = Vendor Grade × batch-COA freshness. Affiliate status is never an input to any grade, and a paying vendor never outranks a non-paying one on a tie.How this works →

Want a clinical path?

Talk to a licensed provider about Retatrutide and whether it's appropriate for your situation.

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PepScore58/100 · C
Last gradedJune 28, 2026
Next re-grade triggerFDA approval of retatrutide would dramatically lift Evidence, Registry, and Practicality axes.

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Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.